Our lab is dedicated to elucidating how various cell compartments maintain their proteome integrity. Protein homeostasis mechanisms are essential for compartment function, and their dysregulation can lead to diseases such as neurodegeneration and cancer. We study protein homeostasis at scale throughout structurally complex cells such as neurons, with an emphasis on the Golgi apparatus which is vital for protein processing and cell communication. To enable this work, we leverage cutting-edge technologies such as CRISPR, pooled protein tagging (shown here), and optical pooled screens. Our research not only seeks to uncover the diverse aspects of protein homeostasis but also aims to harness these pathways via small molecule "glues" or “tacks” to target and modify pathogenic substrates, offering new approaches for disease treatment.